Zentalis Pharmaceuticals, Inc. (ZNTL) Stock

Zentalis Pharmaceuticals, Inc. (ZNTL) is a Healthcare stock trading at $3.82 (as of 2026-08-21), with a market capitalization of $271.93M. Figures are sourced from first-party U.S. SEC EDGAR filings and market data.

Zentalis Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, focuses on discovering and developing small molecule therapeutics for the treatment of various cancers. Its lead product candidate includes the ZN-c3, an inhibitor of WEE1, a protein tyrosine kinase, which is in Phase 2 clinical trial for the treatment of advanced solid tumors; Phase 1/2 clinical trial for the treatment of advanced solid tumors as a monotherapy and in an ongoing Phase 1b clinical trial in combination with chemotherapy in patients with platinum resistant ovarian cancer; and Phase 2 monotherapy trial for a tumor agnostic, predictive biomarker. The company's other lead product candidate includes ZN-c5, an oral selective estrogen receptor degrader that is in a Phase 1/2 clinical trial for the treatment of advanced estrogen receptor-positive, human epidermal growth factor receptor 2-negative, or advanced or metastatic breast cancer. In addition, it is involved in developing ZN-d5, a selective inhibitor of B-cell lymphoma 2 that is in a Phase 1 clinical trial for the treatment of non-Hodgkin's lymphoma and acute myelogenous leukemia; and ZN-e4, an irreversible inhibitor of mutant epidermal growth factor receptor, which is in Phase 1/2 clinical trial for the treatment of advanced non-small cell lung cancer. Further, the company is developing BCL-xL heterobifunctional degraders based on E3 ligases not expressed in platelets, allowing for the avoidance of dose-limiting thrombocytopenia associated with BCL-xL inhibitors. Zentalis Pharmaceuticals, Inc. has licensing agreements and strategic collaborations with Recurium IP Holdings, LLC; Mayo Foundation for Medical Education and Research; SciClone Pharmaceuticals International (Cayman) Development Ltd.; Pfizer, Inc.; Eli Lilly and Company; GlaxoSmithKline, and Zentera Therapeutics (Cayman), Ltd. The company was incorporated in 2014 and is based in New York, New York.

Understand Zentalis Pharmaceuticals, Inc.: how it makes money

Zentalis Pharmaceuticals develops small-molecule cancer therapies, with its lead candidate ZN-c3 in multiple clinical trials, and it currently has no product revenue disclosed in the provided latest-quarter figures.

The company’s profit model is primarily driven by whether ZN-c3 demonstrates clinical effectiveness and tolerability across its ongoing studies, because it is a clinical-stage biopharmaceutical company rather than a provider of already commercial products.

Business quality (Weak): Clear clinical focus on ZN-c3 with reported efficacy and safety metrics, but the company is still in development and shows a materially negative operating margin in the latest-quarter figures.

Bull case

  • Clinical efficacy signals reported for ZN-c3: Overall Response Rate is 39.1% and Clinical Benefit Rate is 58.7% (with Median Duration of Response 5.6).
  • Potential enrichment by biomarker subgroup is reported: Overall Response Rate is 41.4% in Cyclin E1-positive patients and 35.7% in Cyclin E1-negative patients.

Bear case

  • Safety and tolerability concerns in the trial metrics provided: Fatigue occurs in 60.9% of patients, anemia in 58.7%, and patients discontinued due to adverse events are 32.6%.
  • The business has not reached profitability yet: Operating margin is -61.1% in the latest-quarter figures provided, consistent with a clinical-stage development cost structure.
Valuation — source: SEC EDGAR (first-party)
Price$3.82
Market Cap$271.93M
Price / Book1.89
FCF Yield-47.1%
Profitability & Growth — source: SEC EDGAR
Revenue (TTM)$0.00
Revenue Growth (YoY)-100.0%
EPS Growth (YoY)-18.0%
FCF Growth (YoY)-26.8%
Financial Health — source: SEC EDGAR
Altman Z-Score-4.38 (distress)
Valuation vs Sector & Industry
Sector P/E (Healthcare)21.7
Industry P/E (Pharmaceutical Products)17.2
Smart-Money Activity — SEC Form 4 / 13F / Congressional disclosures
Top Institutional Holder5AM Venture Management, LLC ($9.24M)
Institutional Holders Tracked10
Company
SectorHealthcare
IndustryPharmaceutical Products
CEOJulie Eastland
Employees166
CountryUS
IPO Date2020-04-03

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ZNTL earnings history · ZNTL institutional & insider holders · ZNTL KPIs & operating metrics · ZNTL financials · ZNTL investor presentations & press releases · ZNTL SEC filings · ZNTL peers · Congress trades · Insider trades · Short interest · Stock screener

Data as of 2026-08-21.

Figures sourced from U.S. Securities and Exchange Commission (SEC EDGAR) filings and market data. Not personalized investment advice.