Sionna Therapeutics, Inc. (SION) Stock

Sionna Therapeutics, Inc. (SION) is a Healthcare stock trading at $37.29 (as of 2026-06-18), with a market capitalization of $1.93B and a trailing P/E of 0.1. Figures are sourced from first-party U.S. SEC EDGAR filings and market data.

Sionna Therapeutics, Inc. is a biopharmaceutical company developing medicines aimed at normalizing the function of the cystic fibrosis transmembrane conductance regulator (CFTR). Its work is directed toward treatment approaches for patients with cystic fibrosis.

Valuation — source: SEC EDGAR (first-party)
Price	$37.29
Market Cap	$1.93B
P/E Ratio	0.1
EV / EBITDA	-19.0
Price / Book	6.71
DCF Value (model)	$-23.90
DCF Upside vs Price	-164.1%

Profitability & Growth — source: SEC EDGAR
Revenue (TTM)	$13.29M
Net Margin	-566.1%
Return on Equity	-29.7%
Current Ratio	22.60
Revenue Growth (YoY)	62.7%
EPS Growth (YoY)	-88.2%
FCF Growth (YoY)	26.2%

Financial Health — source: SEC EDGAR
Altman Z-Score	51.54 (safe)

Valuation vs Sector & Industry
Stock P/E	0.1
Sector P/E (Healthcare)	21.0
Industry P/E (Pharmaceutical Products)	17.3
vs Sector	-99.7%
vs Industry	-99.6%

Smart-Money Activity — SEC Form 4 / 13F / Congressional disclosures
Top Institutional Holder	RA CAPITAL MANAGEMENT, L.P. ($397.09M)
Institutional Holders Tracked	10

Company
Sector	Healthcare
Industry	Pharmaceutical Products
CEO	Michael Cloonan
Employees	41
Country	US
IPO Date	2025-02-07

Related Companies (Business model: Biotech (Clinical / Commercial-Stage); 8 closest by market cap; US-domiciled)

Data as of 2026-06-18.

Figures sourced from U.S. Securities and Exchange Commission (SEC EDGAR) filings and market data. Not personalized investment advice.