Upstream Bio, Inc. (UPB) ownership: Top institutional holder: FMR LLC ($72.91M). Insider activity: Net Seller (0 buys, 20 sells). SEC EDGAR first-party data.
| Holder | Shares | Market Value | Reported |
|---|---|---|---|
| FMR LLC | 8101563.00 | $72.91M | 2026-03-31 |
| VANGUARD GROUP INC | 2388439.00 | $64.85M | 2025-12-31 |
| ORBIMED ADVISORS LLC | 5693589.00 | $51.24M | 2026-03-31 |
| JANUS HENDERSON GROUP PLC | 1527958.00 | $41.42M | 2025-12-31 |
| Omega Fund Management, LLC | 1326293.00 | $36.01M | 2025-12-31 |
| VR ADVISER, LLC | 1169298.00 | $31.75M | 2025-12-31 |
| BlackRock, Inc. | 3370689.00 | $30.34M | 2026-03-31 |
| Decheng Capital LLC | 2724868.00 | $24.52M | 2026-03-31 |
| Insider | Transaction | Value | Date |
|---|---|---|---|
| Sell | null | 2026-06-16 | |
| Sell | null | 2026-06-16 | |
| Sell | null | 2026-06-16 | |
| Sell | null | 2026-06-16 | |
| Sell | null | 2026-06-16 | |
| Sell | null | 2026-06-09 | |
| Sell | null | 2026-06-09 | |
| Sell | null | 2026-06-09 |
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Institutional data from SEC Form 13F. Insider data from SEC Form 4. Congressional data from STOCK Act disclosures. Not personalized investment advice.