Spyre Therapeutics, Inc. (SYRE) ownership: Fairmount Healthcare Fund II L.P. 25% · institutions 126% · index and ETF funds 5% (13F 2026-06-30). Insider activity, 90 days: 36 sales, 0 open-market buys. SEC EDGAR first-party data.
| Holder | Shares | Market Value | % Outstanding | Reported |
|---|---|---|---|---|
| FMR (Fidelity) | 13026187.00 | $1.16B | 15.0% | 2026-06-30 |
| BlackRock | 6506605.00 | $577.66M | 7.5% | 2026-06-30 |
| Vanguard | 6423758.00 | $570.30M | 7.4% | 2026-06-30 |
| Perceptive Advisors LLC | 4319496.00 | $383.48M | 5.0% | 2026-06-30 |
| RTW Investments, LP | 4251996.00 | $377.49M | 4.9% | 2026-06-30 |
| Paradigm Biocapital Advisors LP | 3840778.00 | $340.98M | 4.4% | 2026-06-30 |
| Capital Group | 3270749.00 | $290.38M | 3.8% | 2026-06-30 |
| State Street | 3057416.00 | $271.44M | 3.5% | 2026-06-30 |
| Insider | Transaction | Value | Date |
|---|---|---|---|
| Sell | null | 2026-09-01 | |
| Sell | null | 2026-09-01 | |
| Sell | null | 2026-09-01 | |
| Sell | null | 2026-09-01 | |
| Sell | null | 2026-09-01 | |
| Sell | null | 2026-09-01 | |
| Sell | null | 2026-09-01 | |
| Sell | null | 2026-09-01 |
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Institutional data from SEC Form 13F. Insider data from SEC Form 4. Congressional data from STOCK Act disclosures. Not personalized investment advice.