Spyre Therapeutics, Inc. (SYRE) ownership: Top institutional holder: FMR LLC ($594.23M). Insider activity: Net Seller (0 buys, 20 sells). SEC EDGAR first-party data.
| Holder | Shares | Market Value | Reported |
|---|---|---|---|
| FMR LLC | 11781024.00 | $594.23M | 2026-03-31 |
| BlackRock, Inc. | 5521221.00 | $278.49M | 2026-03-31 |
| RTW INVESTMENTS, LP | 4171996.00 | $210.44M | 2026-03-31 |
| Fairmount Funds Management LLC | 4018101.00 | $202.67M | 2026-03-31 |
| PERCEPTIVE ADVISORS LLC | 3783225.00 | $190.83M | 2026-03-31 |
| Venrock Adviser, LLC | 3685448.00 | $185.89M | 2026-03-31 |
| VANGUARD CAPITAL MANAGEMENT LLC | 3057401.00 | $154.22M | 2026-03-31 |
| Driehaus Capital Management LLC | 2790785.00 | $140.77M | 2026-03-31 |
| Insider | Transaction | Value | Date |
|---|---|---|---|
| Sell | null | 2026-06-03 | |
| Sell | null | 2026-06-03 | |
| Sell | null | 2026-06-03 | |
| Sell | null | 2026-06-01 | |
| Sell | null | 2026-06-01 | |
| Sell | null | 2026-06-01 | |
| Sell | null | 2026-06-01 | |
| Sell | null | 2026-06-01 |
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Institutional data from SEC Form 13F. Insider data from SEC Form 4. Congressional data from STOCK Act disclosures. Not personalized investment advice.